Effect of one-month treatment with methylphenidate on salivary cortisol level of attention deficit hyperactivity disorder children

Abstract Background Attention deficit hyperactivity disorder (ADHD) is one of the most common neuropsychological disorders that affects children, adolescents, and adults. Dysfunction hypothalamic-pituitary-adrenal axis (HPA) has been implicated in its pathophysiology. So, this study aimed to compare salivary cortisol level between ADHD children healthy children. It also compared before treatment 1 month after with methylphenidate. Results This showed there was a statistically significant decrease group, specifically hyperactive/impulsive subtype control group. Furthermore, it increase Conclusions HPA dysfunction may be related pathophysiology ADHD, subtype. Methylphenidate positively